I strongly recommend suppressing the first sentence off section step three

We surmise that results obtained from the experiments described in this section cannot serve to understand the role of I_NaL in arrhythmogenesis.

step one. Van Driessche W, Lindemann B: Amount reliance out-of currents thanks to solitary salt-choosy skin pores inside frog facial skin. Character. 1979; 282 (5738): 519-520 PubMed Abstract | Author Complete Text message

It indicates the new good findings put forward from this manuscript is actually maybe not justified and that i do not accept brand new manuscript within this setting

The brand new authors enjoys explained many of the questions I elevated into the my personal earlier in the day remark. Unfortuitously, most of the big troubles have not been managed from this modify. Once i produced in my personal earlier in the day review, I consider they unlikely that every those issues are solved only because of the a few additional sentences. Instead you may still find some important concerns towards experimental framework and, most vitally, towards the data.

This means the brand new good conclusions put forward from this manuscript was not justified and that i never accept the fresh new manuscript contained in this setting

Brand new article authors has clarified many of the concerns I increased in the my past opinion. Regrettably, most of the major problems haven’t been managed by this revision. While i manufactured in my personal earlier in the day comment, We deem it unlikely that people things can be repaired merely of the a few added paragraphs. Rather there are still specific simple issues on experimental construction and you will, very significantly, into research.

• The best issue is that if We followed the new malfunction regarding the ways in the previous variation it absolutely was you’ll to help you decode, having almost perfect accuracy, one arbitrary stimuli labels We chose. Find for examples of this reanalysis. Whether or not we pretend the genuine stimulus featured during the an afterwards big date otherwise are consistently changing between laws and quiet, brand new decoding is definitely close to prime. This might be a sign that the decryption has nothing doing for the actual stimulus read from the Sender but is opportunistically exploiting additional features throughout the research. The fresh new control investigation the fresh authors performed, treating this new stimuli labels, don’t address this problem because is suffering from equivalent disease. Basically, exactly what the classifier are presumably using it’s time who’s introduced once the recording been.
• The reason for this can be presumably the article authors put low-independent study having degree and you will analysis. Just in case I’m sure truthfully (select area step three), random testing 1 / 2 of data samples out-of a keen EEG shadow commonly independent studies. Continual the study 5 times – new control research the brand new article writers did – isn’t an acceptable way to address it question. Randomly selecting products regarding a time collection which has slow transform (like the sluggish wave pastime one to presumably reigns over such tracks below these scenarios) have a tendency to inevitably incorporate strong temporary correlations. Get a hold of TemporalCorrelations.jpg in for 2D occurrence histograms and you will a correlation matrix showing it.
• Once the changed steps area brings more detail now, it still is unclear about what study were utilized. Conventional group investigation declaration exactly what studies has actually (typical columns on investigation matrix) and you will just what findings (usual rows) were used. Some thing would be an element but usually this really is the fresh some other EEG channels or fMRI voxels etc. Observations are often date situations. Here I assume brand new article authors transformed the new raw products with the an excellent some other area playing with principal parts studies. This is not said whether your dimensionality try faster using the eigenvalues. In any event, I suppose the details products (amassed at the 128 Hz) was up coming put due to the fact observations together with EEG avenues switched buying a dissertation of the PCA were utilized due to the fact features. The stimuli brands have been assigned given that To the otherwise Of for each and every take to. A set of fifty% of trials (and you will names) was then selected at random for training, plus the others was utilized getting review. Is this best?

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